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KMID : 0604520100360030215
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Journal of the Society of Cosmetic Scientists of Korea
2010 Volume.36 No. 3 p.215 ~ p.219
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The Effect of Hair Growth and Distribution by Sophorae Radix, Panax ginseng, Salvia miltiorrhiza BUNGE Water Extracts
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Hwang Cho-Won
Sim Jae-Wan
Kim Sang-Tae
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Abstract
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In this study, we investigated effects of Monegy (mixture of Sophorae Radix, Panax ginseng, Salvia miltiorrhiza BUNGE) on epilate-induced hair-loss in dorsal region of C57/BL6 mice and external structure of human hair. For morphological and histological analysis in scalp of epilate-induced hair-loss animal model, we utilized several microscopic techniques, such as confocal laser scanning microscopy (CLSM) and LAS 4000. Confocal analysis showed the distribution of FITC-conjugated Monegy and penetration depth compared with normal and control group. Furthermore, when Monegy was topically administrated onto a C57BL6 mouse, it penetrated very well. The fluorescence intensity was increased upto 205 and 113 folds compared to normal and control group, respectively. Also, area of fluorescence was increased to upto 255 to 127 folds compared to normal and control group. Broad scale area of fluorescence in dermis region was observed in the Monegy-treated mice. Furthermore, Monegy induced upto 75% hair repair against depilation. It might be promoted via the induction of growth factors in hair follicle.
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KEYWORD
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hair growth, confocal, hromone, hair component
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